OrbusVR does not officially support Mixed reality headsets and I heard multiple times that there are some small problems only experienced by users with mixed reality headsets (like lack of vibration in certain situations). But I also keep hearing that the game is playable. But no guarantee of-course. For your Acer Mixed Reality HMD specifically I found a few posts of people mentioning they also used the Acer headset. So there is a high probability it will work.