I did some poking back through the alpha and runemage hype threads and I don’t believe Riley has any intention of reworking the runes again. They should all be in their final forms unless something totally bizarre happens.
What I think he does intend to do before the next test is to retrain the rune matching algorithm for the portal and resurrection runes so they are more distinct and so the correct portal runes take you to the right places.
This is just what I was able to gather. Maybe that has changed since and I missed the post.